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The Brookdale Foundation Group

300

Frank W. Burr Blvd

Suite 13

Teaneck, NJ

07666

 

Phone:

201-836-4602

 

Fax:

201-836-4342

 

Andrea C. Gore, PhD

Andrea Gore

Dr. Andrea Gore is the Gustavus & Louise Pfeiffer  Professor at the University of Texas Austin/Div of Pharmacology/Toxicology. Dr. Gore received a BA in Biology from Princeton University and a PhD in Neuroscience at the University of Wisconsin, Madison. She did her postdoctoral training, first as an NRSA Fellow and then as a Revson Foundation Fellow, in the laboratory of Dr. James L. Roberts at the Mount Sinai School of Medicine.

Dr. Gore’s Brookdale proposal focused on characterizing neuroendocrine changes in aging rats and rhesus monkeys as a model for menopause in women. Her studies measured changes in levels and gene expression of several neurotransmitters in aging brains, and the impact of the ovarian steroid hormone estrogen on these alterations in the central nervous system. Experiments were performed at molecular, anatomical and physiological levels in order to put together a comprehensive picture of the aging neuroendocrine axis. For more information about Dr. Gore's work, click here.

Research Interests
The goal of work in the Gore Laboratory is to understand the neuroendocrine control of reproduction and sex differences in the brain during development and aging. We are interested in hormone actions (especially estrogens) in the brain, and perturbation of these processes by environmental hormone disruptors. One line of research focuses on molecular and cellular changes to the aging female hypothalamus, and estrogen effects on the aging brain as a model for menopause. A second line of research seeks to understand how prenatal exposure to environmental endocrine disruptors (EDCs) causes molecular epigenetic modifications and cellular changes to the developing hypothalamus and the manifestations of these effects later in life, and transgenerationally. The outcomes of this developmental reprogramming by EDCs include perturbations in brain structure, neural phenotypic properties, and sexually dimorphic behaviors in adulthood. Our team uses comprehensive behavioral, physiological, neuroanatomical, immunohistochemical (light and electron microscopy), and molecular approaches to address these questions on the neurobiological control of reproduction across the life cycle.

Dr. Gore is also the Editor-in-Chief for Endocrinology

Brookdale Fellow Class of 1997

8/09